Spam filters and Blocked list

I am having some spam problems.  I have put filters in place with the many partial email addresses used.  I used must contain instead of exact addresses.  And I even put many of them on the blocked list.  They are still getting through.  I try to add them again just in case and it tells me that address is already blocked.  But they are not being blocked.  

Any advise out there?

TORYnSD