Programming TV remote to mini box?

Is it possible to program a TV (smart) remote to use on a cox mini box?

right now I’m having to use 2 remote, the remote than cane with the tv and the cox remote for when I want to watch cable.

It would be nice to only have to use 1 remote -my TV’s remote has the numbers & channel up/down button it’s only missing a guide button. I also have mini HDMI connected to ARC HDMI and it doesn’t do anything.