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When I select Guide the green light on the remote comes on but nothing happens. In fact, any button I push does nothing. I can't change the channel or do anything at all. I have replaced the batteries.
Do the buttons on the box work? If not, reboot the box. If so, try changing the batteries in the remote. If that doesn't work, try getting a new remote at the store.
PS. What kind of remote do you have? See here for the different kinds and their names. Hold CTRL before clicking to open in a new tab.
Is it a new remote or cable box? After I replaced my remote and programmed it for my TV (Mute + Select then 4-digit code), it wouldn't work. I had to read the instructions.
I also had to program it for the cable receiver. For Scientific Atlanta with Rovi: Press Cable button, simultaneous Swap + A, Cable button blinks twice.
Things have evolved since Rovi. However, I read the instruction for a newer remote (Contour 2 Voice) and there is still a pairing process: Pair Your Remote for Voice Control. Even though you may not want voice control, it still pairs the remote to the receiver. I'll assume all remotes need to be paired.